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Lab-on-a-chip for
hi-volume disposables & integrated chemical assays
Chemistry to run assays have been integrated
onto disposable wafers. These types of products are sometimes called "lab-on-a-chip" or "systems-on-a-chip".
The products usually use manufacturing techniques called MEMS (see below write-up on this page).
These assays can come in the form of arrays, wells, micro-channels, or surface coatings.
Various projects have involved disposables with quantities up to 1 million per month. These projects usually
included designing the products as well as the equipment needed to produce the parts.
Miniaturizations and
MEMS
Researched, designed, and analyzed for components, modules, and systems including the following: MEMS,
nanotechnologies, microfluidics, nanoliter injection, automatic optical
positioning within microns, repeatable optical alignments for disposables, micro pumps, miniature valves,
multiple capillary arrays/channels, diverse miniaturized fluid connections,
and capillary electrophoresis (see the patents section of the
credentials page for capillary-related items). Micro-Electro-Mechanical Systems (MEMS) refers to a variety
of technologies.
One MEMS reference is to its use as an integration of mechanical elements, sensors, actuators, and
electronics on a common substrate. While the electronics are fabricated using integrated
circuit (IC) methodologies from the semiconductor industry, the mechanical components are fabricated using
compatible micro machining (removing or adding materials in small quantities at a time).
Another MEMS reference is to its use as a replacement for chemistry based tests previously done on capital
equipment or as wet lab processes done by Ph D's. By miniaturizing these processes onto
a chip, significant reductions can be made to test cost, test time, materials used, and hazardous waste
disposal. Space here does not allow for a full discussion of the almost daily innovations
in MEMS technologies.
Optical interfaces,
and lasers
Developed method to focus a wide spectrum of light into capillary tubes down to 25 micron internal
diameters (see patents page for capillary-related items). Other developments have included fiber optic
interfaces both molded fix positioned and with extended flexible cabling. Troubleshot problems with
molding plastic lens including elimination of sink, uneven light projection, polishing, and coating.
Researched substitution of a plated molded plastic component for an assembly of mirrors onto a casting
in a spinning bar code reader. Molded parts for trial were delivered within 2 months.
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